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Recent research has discovered that a gene variant may predict naltrexone treatment success for alcoholism. About 50% of patients of Asian descent possess a particular mutation that makes them prone to benefit from naltrexone, weighed against about 20% of Caucasians and much less than 5% of African Americans, said lead study author Lara Ray, an assistant professor of psychology and director of the UCLA Addictions Laboratory. The findings are currently available online ( within the journal Neuropsychopharmacology and you will be published in a upcoming print edition with the journal. Using two separate drugs to shed weight can be very effective you will find combinations as you're watching FDA now awaiting approval. When dealing with weight-loss and the individuals who go through it you should err along the side of caution and let the FDA do its job and demand some investigation be done so the public recognizes the side effects and perils associated with the medications before we take them. Keep in mind that drug companies will be in business to generate money and that they would say everything to keep people on their medications. Researchers found out that participants taking this drug for the year, lost weight within 4 weeks and have kept the weight off during the entire 56 weeks of the study. Contrave can be a combination of the drugs naltrexone and bupropion, which generally seems to reflect a fresh trend of weight-loss drugs that are made up of many active ingredient, that might make them more efficient and safer. Combo-pilling will be the newest fad or in addition to this the newest ahead under scrutiny and so it is just more publicly known although in the past, comb-pilling for weight loss has been around since the eighties. The biggest reason that utilizing a combination of pills is starting to become popular is the fact that at the time of right now there are no long term prescription weightloss pills that have been approved by the FDA apart from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications although some people might of the combinations have been rejected or have yet to be licensed by the FDA. Seizures really are a side effect with Contrave and shouldn't be taken in people who have seizure disorders. The drug could also raise hypertension and heart rate, and mustn't be used in people who have a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy using the drug. The FDA also warned that Contrave can raise blood pressure and heartbeat and must stop used in patients with uncontrolled high blood pressure, in addition to by anyone with heart-related and cerebrovascular (circulation dysfunction impacting the brain) disease. Patients having a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes with a boxed warning to alert medical professionals and patients on the increased risk of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for quitting smoking. 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