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Using two separate drugs to lose weight can be very effective you will find combinations in front of the FDA now awaiting approval. When dealing with weight reduction and the people who go through it you should err on the side of caution and let the FDA do its job and demand some investigation be done so that the public recognizes the side effects and dangers of the medications before we take them. Keep in mind that drug companies come in business to generate income and that they would say anything to keep people on the medications. Researchers found out that participants taking this drug for the year, lost weight within one month and have kept the weight off throughout the 56 weeks of the study. Contrave is really a combination in the drugs naltrexone and bupropion, which generally seems to reflect a new trend of weight-loss drugs which might be made up of multiple active ingredient, which might make them more efficient and safer. Combo-pilling may be the newest fad or better yet the newest into the future under scrutiny and for that reason it is just more publicly known recently, comb-pilling for weight reduction has been around since the eighties. The biggest reason that using a combination of pills is now popular is the fact that since right now there aren't long term prescription weight loss supplements that have been licensed by the FDA besides orlistat. The truly disturbing part is doctors are prescribing these combinations of medications even though some of the combinations have been rejected or have yet to be licensed by the FDA. Seizures certainly are a side effect with Contrave and really should not be taken in those with seizure disorders. The drug also can raise blood pressure levels and heart rate, and mustn't be used in people with a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise blood pressure levels and heartrate and must 't be used in patients with uncontrolled high blood pressure levels, along with by you aren't heart-related and cerebrovascular (circulation dysfunction impacting mental performance) disease. Patients with a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients towards the increased likelihood of suicidal thoughts and behaviors associated with antidepressant drugs. 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